IGH-CCND1 Fusion/Translocation FISH Probe Kit - 10 tests

The IGH-CCND1 FISH probe set is designed to detect rearrangements involving regions of the human IGH locus, located on chromosome band 14q32.33, and of the human CCND1 gene on 11q13.3. The kit contains two differentially labeled Locus Specific Probe (LSP) pairs. One set of probes covers the 5’ (start) portion of the CCND1 gene and some upstream untranslated genomic sequence as well as sequences downstream of the 3’ (end) part of the gene. The two probes are flanking sequences in the CCND1gene in which both a 3’ breakpoint cluster as well as several individual breakpoints have been observed.

The second probe pair spans the immunoglobulin heavy chain gene locus (IGH@) and consists of a portion matching the 5’ (start) region encoding variable gene segments (IGHV), and a part that covers the 3’ (end) and downstream sequences. This probe pair is flanking an area of the IGH gene comprising constant gene segments (IGHC) as well as the delta segment (IGHD), joining region (IGHJ) and epsilon domain (IGHE). Almost all known breakpoints in IGH@ have been mapped to this region.

For Research Use Only.