Cyclin D3 - Mouse Monoclonal APM241

Cyclin D3, also known as CCND3, is a human gene. The protein encoded by this gene belongs to the highly-conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of Cdk kinases. This cyclin forms a complex with and functions as a regulatory subunit of Cdk4 or Cdk6, whose activity is required for cell-cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. The Cdk4 activity associated with this cyclin was reported to be necessary for cell-cycle progression through G2 phase into mitosis after UV radiation. In normal adult tissues, Cyclin D3 shows two patterns of distribution: in lymphoid tissues it is expressed in proliferative compartments, while in most other tissues it is expressed by terminally differentiated/quiescent cells. In non-Hodgkin’s Lymphomas, Cyclin D3 immunolabelling correlates with proliferative activity and progression. Benign endocrine tumors are frequently strongly Cyclin D3-positive, while high-grade (Small-cell) Neuroendocrine Carcinomas are always negative. In Breast Carcinomas, no relationship has been seen between ER status and Ki67 labelling. In soft tissue neoplasms, Cyclin D3 is consistently expressed in some tumors, such as Stromal Tumors of the Gastrointestinal Tract and Embryonal Rhabdomyosarcomas.

Available options include prediluted (3ml, 7 ml, 15ml), concentrate (0.1 ml, 0.5ml, 1ml) and 5+ control slides.

For Research Use Only.